RESULTS OF THE STUDY OF THE TOTAL POLYSACCHARIDES FROM FERULA KUHISTANICA AS AN ADAP-TOGENIC MEANS

From the aerial part of Ferula kuhistaniсa, the sum of polysaccharides was isolated, their physicochemical parameters and monosaccharide composition were determined. The amount of polysaccharides was standardized. In experiments on male mice weighing 18–20 g was found that the extractive preparation of polysaccharides isolated from Ferula kuhistanica when administered orally at a dose of 250 mg/kg has a pharmacocorrective effect on the alarm reaction in animals under conditions of acute stress, significantly increases physical performance and quickly relieves fatigue. In addition, the studied preparation of polysaccharides has a protective effect in case of alcohol poisoning, sodium nitroprusside, gamma irradiation. By the direction of its action, the amount of polysaccharides from F. kuhistaniсa resembles the action of known adaptogenic agents: ecdysten (not much inferior to it in activity) and еleutherococcus liquid (extract has a similar effect).