CHEMICAL COMPOSITION OF ESSENTIAL OILS OF THE ABOVE GROUND PART OF TWO SPECIES OF PLANTS OF THE GENUS HAPLOPHYLLUM GROWING IN UZBEKISTAN

Various species of plants of the genus Haplophyllum (family Rutaceae) have long been used in folk medicine to treat skin and nervous diseases, as an antidote for poisoning, an antipyretic, analgesic, laxative, and for diseases of the stomach and spleen. Extracts of some species exhibit antioxidant, antibacterial, insecticidal, antiprotozoal, anti-inflammatory, estrogenic, antitumor, and cytotoxic activity. Therefore, they attract the attention of researchers as potential sources of biologically active substances with valuable pharmacological properties. The component composition of the essential oil (EO) obtained by hydrodistillation from the aboveground part of the plant Haplophyllum acutifolium (DC.) G. Don fil. 64 compounds were found in the EO oil from the aboveground part of H. acutifolium by GC-MS, which is 92.5% of the oil weight. 58 components were identified. It was found that EO is a rich source of terpenes and its composition is dominated by sesquiterpene hydrocarbons (44.1%) and oxidized sesquiterpenes (19.7%), while the content of monoterpenes and oxidized monoterpenes is only 4.1 and 4.8%, respectively. The main components of EO are α-elemol (12.6%), germacrene B (12.5%), β-caryophyllene (8.4%), 3-methyl-2-butenal (4.9%), germacrene D (4.5%), δ-cadinene (3.1%), δ-selinene (3.0%), alloarmadendrene (2.5%), spathulenol (2.4%). In the composition of EO from the aboveground part of Haplophyllum ferganicum Vved. 31 components were identified, which makes up 97.2% of the total mass of the oil. It was found that H. ferganicum EO is a rich source of terpenes and its composition is dominated by monoterpene (37.2%) and sesquiterpene hydrocarbons (35.0%). The content of oxidized monoterpenes and oxidized sesquiterpenes in the EO is only 10.2 and 5.4%, respectively. The main components of the EO are germacrene B (19.7%), limonene (15.2%), α-phellandrene (10.7%), 3-methyl-2-butenal (6.2%), β-phellandrene (5.0%), β-caryophyllene (4.3%), terpinolene (3.9%), γ-elemene (3.2%) and linallyl acetate (2.6%).