TECHNOLOGY FOR OBTAINING A SUBSTANCE WITH A SEDATIVE EFFECT FROM COMBINED PLANT RAW MATERIALS CONSISTING OF AERIAL PART OF URTICA DIOICA, MELISSA OFFICINALIS AND LEONURUS TURCESTANICUS

The process of extraction of flavonoids and phenolic acids from a combined raw material consisting of aerial parts of Urtica dioica L., Melissa officinalis L. and Leonurus cardiaca Krecz was studied. et Kupr. in a ratio of 1 : 1 : 1, five-fold extraction with 70% ethyl alcohol at room temperature, with infusion for 6 hours was proposed. This extraction condition ensures the extraction of 95.45% of flavonoids and 86.25% of phenolic acids from the content in the raw material. To purify the extract, a liquid-liquid extraction method has been proposed, in which the concentrated extract is diluted with water and treated four times with extraction gasoline to remove lipophilic impurities. To obtain dry extract "Sedex", spray drying is recommended under the following conditions: coolant temperature at the inlet 175±5 °C and outlet 80±2 °C, solution supply rate – 4 l/h, air pressure supplied to the nozzle – 0.15 MPa and solution concentration – 20%. A technology has been developed for the production of a sedative substance in the form of a dry extract from combined raw materials, which is conventionally named "Sedex". The proposed technology ensures the production of a dry extract with a yield of 14.5% by weight of the raw material containing no less than 4.8% of the total flavonoids in terms of rutin and no less than 14.3% of phenolic acids in terms of rosmarinic acid.