Current Landscape and Future Directions for Dengue Vaccines: Addressing a Global Health Challenge

Dengue is the most common arboviral infection, causing significant morbidity and mortality. Currently, more than half of the world’s population is at risk, particularly in tropical and subtropical regions of Asia, with the virus now spreading to new areas in Europe and the Americas, a silent epidemic in Africa. Current efforts including dengue surveillance, partially effective vaccines, innovative vector control strategies, and a better understanding of the disease pathogenesis are significant. We argue that the future of dengue prevention requires more than just the advancements made so far. The development of a highly effective vaccine, paired with enhanced public health strategies, is essential for long-term control and reducing the global impact of dengue.