ANTIVIRAL ACTIVITY OF POLYPHENOLS OF THE LEAVES OF SUMACH RHUS CORIARIA L.

The aim of this study is to improve the technology for obtaining the amount from the leaves of tannic sumac Rhus coriaria L. with an increase in the yield of the main individual polyphenols and to study the antiviral activity against the 3CLpro viral protease. As a result of the research, the technology for obtaining the sum of components and the main individual polyphenols from the leaves of tannic sumac Rhus coriaria L. was improved. It was determined that with a change in the acid number of a 40% ethanol solution to 8.5, the content of active components in the total extract increases to 73.93%, increasing by 1.82 times in relation to the total extract obtained by the previously published method, and making up the maximum among all examples of obtaining the total extract. As a result of studying the inhibition of the main protease, it was shown that the substance and individual polyphenols obtained using the improved technology exhibit a higher percentage of inhibition of the main protease of the coronavirus, with IC50 values of 1.4-2.6 μm, show the presence of synergism in the inhibitory activity of the main components, manifested in increased inhibition of the main protease (Mpro) of SARS-CoV-2 in total and, thus, confirm the promise of use as a safe antiviral drug.