COMPARISON OF THE CHEMICAL COMPOSITION AND ASSESSMENT OF GENOTOXICITY OF AQUEOUS EXTRACTS FROM THE AERIAL PARTS OF RANUNCULUS ACRIS (L.) USING THE ALLIUM TEST

Ranunculus acris (L.) is a common plant with poisonous properties and used in folk medicine. The use of herbal medicines requires the study of chemical composition, toxicity and genotoxicity. The aim of the study was to compare the toxic and genotoxic effects of aqueous solutions of R. acris organs from the sites of the botanical garden in Apatity and Kirovsk in concentrations of 0.625, 1.25, 2.5, 5 and 10% using an Allium test. The objects of the study were 6 samples of various above ground organs of the buttercup, harvested in the summer in two different places of growth and cultivation. The study of the chemical composition was carried out using standard methods for the determination of BAS in plant tissues. The Allium test was carried out on an onion of the Stuttgart Riesen variety. It was shown that R. acris flowers from both sites showed high values of antioxidant activity (TAC) leaves and flowers from the site in Kirovsk showed values of the total content of flavonoids (TFC) higher than from the site in Apatites, and leaves from Apatites showed values of the total content of phenols (TPC). Chromosomal aberrations were more common in solutions of R. acris leaves from the Kirovsk site. Solutions of R. acris leaves collected from the site in Kirovsk showed a greater mitodepressive and genotoxic effect compared to solutions of leaves collected from the site in Apatites, in solutions of flowers and stems of R. acris collected from both sites, no such dependence was noted.