RNA-Seq analysis reveals the long noncoding RNAs associated with immunity in wild Myotis myotis bats
We conducted the first ab initio prediction of lncRNAs in a non-model bat species, the wild-caught M. myotis. Our network analysis revealed significant variation in immune status among a subset of individuals, potentially due to pathogenic conditions. From these variations, we identified lncRNAs most likely associated with immune response in bats. This initial exploration lays the groundwork for future experimental validations of lncRNA functions, offering promising insights into their role in bat immunity.
Authors
- Graham M. Hughes (ORCID: https://orcid.org/0000-0003-3088-345X)
- Emma C. Teeling (ORCID: https://orcid.org/0000-0002-3309-1346)
- Frédéric Touzalin (ORCID: https://orcid.org/0000-0002-3042-8986)
- Wilfried Haerty (ORCID: https://orcid.org/0000-0003-0111-191X)
- Zixia Huang (ORCID: https://orcid.org/0000-0002-1298-0486)
- Samuel Carthy (ORCID: https://orcid.org/0000-0001-5841-6031)
- Sébastien Riquier (ORCID: https://orcid.org/0000-0002-4207-2470)
Institutions
- University College Dublin (IE)
- University of East Anglia (GB)
- Earlham Institute (GB)
- University of Glasgow (GB)
Publication Details
- Journal
- BMC Genomics
- Published
- 2025-04-05
- DOI
- https://doi.org/10.1186/s12864-025-11485-1
- Citations
- 1
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Science Foundation Ireland