β-blocker suppresses both tumoral sympathetic neurons and perivascular macrophages during oncolytic herpes virotherapy
Our findings demonstrate that combining a β-blocker with oHSV significantly enhances the antitumor efficacy of oHSV in breast cancer by targeting TGF-β-mediated SNS innervation and immunosuppression.
Authors
- Gang Zhou (ORCID: https://orcid.org/0000-0001-8967-114X)
- David H. Munn (ORCID: https://orcid.org/0000-0002-7711-2858)
- Balveen Kaur (ORCID: https://orcid.org/0000-0001-7738-0804)
- Hui Fang (ORCID: https://orcid.org/0000-0002-3081-5863)
- Konstantina Kyritsi (ORCID: https://orcid.org/0000-0002-7424-2788)
- Eugene F. Douglass (ORCID: https://orcid.org/0000-0003-3418-9203)
- Rafał Pacholczyk (ORCID: https://orcid.org/0000-0002-9629-4829)
- Miao Yu (ORCID: https://orcid.org/0000-0001-8727-1388)
- Bangxing Hong (ORCID: https://orcid.org/0000-0001-7458-0480)
- Qin Wang (ORCID: https://orcid.org/0000-0003-1115-4905)
Institutions
- University of Georgia (US)
- Augusta University (US)
- Augusta University Health (US)
- Georgia Regents Medical Center (US)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1136/jitc-2024-011322
- Citations
- 4
- Primary Topic
- Cancer, Stress, Anesthesia, and Immune Response
- Type
- article
- Field-Weighted Citation Impact
- 5.88
Funders
- Alex's Lemonade Stand Foundation for Childhood Cancer
- National Institute of Neurological Disorders and Stroke