Flagellin engineering enhances CAR-T cell function by reshaping tumor microenvironment in solid tumors
Our study reveals the potential and cellular mechanisms for Fla to rewire antitumor immunity. It also implies that modifying CAR-T cells to express Fla is a viable strategy to improve the efficacy of CAR-T cell treatment against solid tumors.
Authors
- Xiangyun Niu (ORCID: https://orcid.org/0000-0002-0092-0080)
- Liujiang Dai (ORCID: https://orcid.org/0000-0002-2765-2557)
- Pengchao Zhang (ORCID: https://orcid.org/0000-0002-7851-2976)
- Yun Tang (ORCID: https://orcid.org/0000-0002-8807-5239)
- Guizhong Zhang (ORCID: https://orcid.org/0000-0001-8930-5262)
- Xixia Peng (ORCID: https://orcid.org/0000-0002-4940-8029)
- Xiaochun Wan (ORCID: https://orcid.org/0000-0003-3745-1860)
- Zhongming Liu
Institutions
- Chinese Academy of Sciences (CN)
- Shenzhen Institutes of Advanced Technology (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1136/jitc-2024-010237
- Citations
- 5
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 5.23
Funders
- National Natural Science Foundation of China
- Basic and Applied Basic Research Foundation of Guangdong Province