Conformation-sensitive targeting of CD18 depletes M2-like tumor-associated macrophages resulting in inhibition of solid tumor progression

Collectively, our findings suggest that activated CD18 holds promise as a novel target protein for cancer therapy, and TB511 shows potential as a therapeutic agent for tumor treatment.

Authors

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Publication Details

Journal
Journal for ImmunoTherapy of Cancer
Published
2025-04-01
DOI
https://doi.org/10.1136/jitc-2024-011422
Citations
5
Primary Topic
Immune cells in cancer
Type
article
Field-Weighted Citation Impact
3.99

Funders

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article

Conformation-sensitive targeting of CD18 depletes M2-like tumor-associated macrophages resulting in inhibition of solid tumor progression

Hye Duck Yeom, Ik‐Hwan Han, Namgyeong Park, Eun-Ji Ko et al.
5 citations
Journal for ImmunoTherapy of Cancer
Immune cells in cancer
3.99
article

Conformation-sensitive targeting of CD18 depletes M2-like tumor-associated macrophages resulting in inhibition of solid tumor progression

Hye Duck Yeom, Ik‐Hwan Han, Namgyeong Park, Eun-Ji Ko, Heekyung Lee, Hyemin Go, Deok‐Sang Hwang, Jeongyoon Choi, Nari Cha, Hyunsu Bae, Hwan‐Suck Chung, Juwon Yang, Seung Joon Lim, Seong Ho Kang, Chanmi Jeong, Sehyun Pak, Minjin Kwon, Ilseob Choi, Hong-Sung Kim, Jun‐Ho Lee, Soyoung Kim, Eun‐Ji Lee, Jin Sun Shin, Hyo-Jung Choi, Yingying Cao, Songah Chae, Won-Jun Lee, Hongseo Choi
article en
5 citations

Abstract

Collectively, our findings suggest that activated CD18 holds promise as a novel target protein for cancer therapy, and TB511 shows potential as a therapeutic agent for tumor treatment.

Journal for ImmunoTherapy of CancerVol. 13(4)
Chonnam National University (KR), Hanwha Techwin (South Korea) (KR), Illinois Department of Public Health (US), Kyung Hee Cyber University (KR), Kyung Hee University (KR), Korea Institute of Oriental Medicine (KR)
National Research Foundation of Korea
Good health and well-being
Openalex Percentile: Top 6%
Immune cells in cancer
3.99
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