Conformation-sensitive targeting of CD18 depletes M2-like tumor-associated macrophages resulting in inhibition of solid tumor progression
Collectively, our findings suggest that activated CD18 holds promise as a novel target protein for cancer therapy, and TB511 shows potential as a therapeutic agent for tumor treatment.
Authors
- Hye Duck Yeom (ORCID: https://orcid.org/0000-0002-0727-8676)
- Ik‐Hwan Han (ORCID: https://orcid.org/0000-0002-8145-6645)
- Namgyeong Park (ORCID: https://orcid.org/0009-0001-0884-3091)
- Eun-Ji Ko (ORCID: https://orcid.org/0000-0002-3758-1019)
- Heekyung Lee (ORCID: https://orcid.org/0000-0001-5700-3331)
- Hyemin Go
- Deok‐Sang Hwang (ORCID: https://orcid.org/0000-0001-9179-0797)
- Jeongyoon Choi (ORCID: https://orcid.org/0000-0001-7501-4069)
- Nari Cha
- Hyunsu Bae (ORCID: https://orcid.org/0000-0002-0299-3582)
- Hwan‐Suck Chung (ORCID: https://orcid.org/0000-0002-5901-0217)
- Juwon Yang (ORCID: https://orcid.org/0009-0008-8460-8027)
- Seung Joon Lim
- Seong Ho Kang (ORCID: https://orcid.org/0000-0003-2101-4113)
- Chanmi Jeong
- Sehyun Pak (ORCID: https://orcid.org/0009-0006-6763-0674)
- Minjin Kwon
- Ilseob Choi (ORCID: https://orcid.org/0000-0001-9698-0899)
- Hong-Sung Kim
- Jun‐Ho Lee (ORCID: https://orcid.org/0000-0003-0913-8578)
- Soyoung Kim (ORCID: https://orcid.org/0000-0003-4918-1087)
- Eun‐Ji Lee
- Jin Sun Shin
- Hyo-Jung Choi (ORCID: https://orcid.org/0000-0002-0584-8006)
- Yingying Cao (ORCID: https://orcid.org/0000-0001-6012-9445)
- Songah Chae
- Won-Jun Lee
- Hongseo Choi
Institutions
- Chonnam National University (KR)
- Hanwha Techwin (South Korea) (KR)
- Illinois Department of Public Health (US)
- Kyung Hee Cyber University (KR)
- Kyung Hee University (KR)
- Korea Institute of Oriental Medicine (KR)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1136/jitc-2024-011422
- Citations
- 5
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 3.99
Funders
- National Research Foundation of Korea