EVALUATION OF ANTHELMINTIC ACTIVITY OF CURCUMA AROMATICA SALISB. TUBER AQUEOUS EXTRACT

The aim of the present study is to evaluate the anthelmintic activity of aqueous extract of rhizomes of Curcuma aromatic Salisb in various concentration (25% to 100%) by using earth worms (Lumbricus rubellus). Albandezole 20mg/mL was used as the standard drug where distilled water as control. A strong association was seen between the concentration gradient and the results. The minimum time for paralysis (15.5 min) and death (34.7 min) was observed in 100% concentration of aqueous extract of rhizomes of Curcuma aromatica Salisb. Maximum time taken for paralysis (46.2 min) and death (105.0) was recorded in the 25% concentration of aqueous extract of rhizomes of Curcuma aromatica Salisb. Time taken for paralysis recorded in 50% and 75% concentration of aqueous extract of rhizomes of Curcuma aromatica Salisb were 34.2 min and 26.9 min accordingly. Time taken for death recorded in 50% and 75% concentration of aqueous extract of rhizomes of Curcuma aromatica Salisb were 67.6 min and 57.6 min accordingly. The results obtained were statistically analyzed by SPSS, IBM, Version 23. Using one way-ANOVA method and paired sample t-test analysis method. The standard used was albendazole at the concentration of 20mg/ml showed a significant value of 0.049 which is P<0.05 which indicates that the standard drug used for the research is an efficient and effective drug which elicited anthelmintic activity. Where as aqueous extract of Rhizomes of Curcuma aromatica Salisb was used as the test drug at the different concentration gradients of 25%, 50%, 75% and 100% against the Earth worms belongs to the species of Lumbricus rubellus which indicates the P values as for 25% (p=0.033, p<0.05), for 50% (p=0.022, p<0.05), for 75% (p=0.014, p<0.05) and 100% (p=0.009, p<0.05). When compared to the standard drug the test drug in all percentage of concentrations indicates effective anthelmintic activity. Among the different concentration gradients with the increase in concentrations, the anthelmintic activity also increased. Therefore, the results of this study conclude that the aqueous extract of rhizomes of Curcuma aromatica Salisb showed anthelmintic activity. Key words: Curcuma aromatica Salisb, Anthelmintic, Earth worms, Albendazole