Influenza A(H1N1)pdm09 Virus with Reduced Susceptibility to Baloxavir, Japan, 2024
Influenza A(H1N1)pdm09 virus carrying an I38N substitution was detected in an untreated teenager in Japan. The I38N mutant virus exhibited reduced susceptibility to baloxavir but remained susceptible to neuraminidase inhibitors and showed reduced growth capability. Monitoring antiviral drug susceptibility of influenza viruses is necessary to aid public health planning and clinical recommendations.
Authors
- Hideka Miura
- Hiroko Morita
- Emi Takashita (ORCID: https://orcid.org/0000-0002-9064-4699)
- Sueshi Ito
- Kazuya Nakamura (ORCID: https://orcid.org/0000-0003-4113-1579)
- Kenichi Komabayashi (ORCID: https://orcid.org/0000-0003-0900-8845)
- Yohei Matoba
- Katsumi Mizuta (ORCID: https://orcid.org/0000-0001-8965-9925)
- Hideki Hasegawa (ORCID: https://orcid.org/0000-0002-6558-2297)
- Shiho Nagata
- Mika Sasaki
- Seiichiro Fujisaki (ORCID: https://orcid.org/0000-0002-6129-8950)
- Masayuki Shirakura
- Shinji Watanabe
- Tomoko Takahashi
- Tatsuya Ikeda
- Noriko Kishida (ORCID: https://orcid.org/0000-0003-4501-568X)
- Naomi Ogawa
Publication Details
- Journal
- Emerging infectious diseases
- Published
- 2025-04-24
- DOI
- https://doi.org/10.3201/eid3105.241123
- Citations
- 3
- Primary Topic
- Influenza Virus Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.06
Funders
- Japan Agency for Medical Research and Development