Delayed neurological recovery in ischemic stroke patients undergoing endovascular treatment is associated with baseline hyperglycemia: a treatable cause of the stunned brain phenomenon?
Successful vessel recanalization was associated with better functional outcome at day 90 independent of BG profiles; however, acute hyperglycemia was significantly linked to delayed neurological recovery. Hence, hyperglycemia might be a major cause of the stunned brain phenomenon and might consequently serve as a promising target for adjunctive therapy in the treatment of ischemic stroke patients.
Authors
- Susanne Gellißen (ORCID: https://orcid.org/0000-0002-7444-7265)
- Gerhard Schön (ORCID: https://orcid.org/0000-0003-2556-6804)
- Uta Hanning (ORCID: https://orcid.org/0000-0002-7543-8555)
- Christian Heitkamp (ORCID: https://orcid.org/0000-0002-8988-0918)
- Helge C. Kniep (ORCID: https://orcid.org/0000-0001-5258-2370)
- Lukas Meyer (ORCID: https://orcid.org/0000-0002-3776-638X)
- Karolin Schulte
- Laurens Winkelmeier (ORCID: https://orcid.org/0000-0002-9103-5983)
- Gabriel Broocks (ORCID: https://orcid.org/0000-0002-7575-9850)
- Matthias Bechstein (ORCID: https://orcid.org/0000-0002-5652-7499)
- Jens Fiehler (ORCID: https://orcid.org/0000-0001-8533-7478)
- Anna Andriana Kyselyova (ORCID: https://orcid.org/0000-0002-8662-0811)
- Marlene Heinze (ORCID: https://orcid.org/0000-0003-3831-0197)
- Susan Klapproth (ORCID: https://orcid.org/0009-0002-9840-0135)
Institutions
- Universität Hamburg (DE)
- University of Zurich (CH)
- MSH Medical School Hamburg – University of Applied Sciences and Medical University (DE)
- University Hospital of Zurich (CH)
- Helios Hospital Schwerin (DE)
- University Medical Center Hamburg-Eppendorf (DE)
Publication Details
- Journal
- Journal of Neurology
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1007/s00415-025-13019-x
- Citations
- 2
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 2.71