A case series of B-Lymphoblastic lymphoma with C-MYC rearrangement in children: diagnostic and therapeutic challenges
C-MYC rearrangement has been listed as a new subcategory of B-cell acute lymphoblastic leukemia (B-ALL) in the latest International Consensus Classification (ICC), but B-cell lymphoblastic lymphoma (B-LBL) with C-MYC rearrangement is extremely rare and therefore is a novel finding worth reporting. In this study, we described a small number of pediatric cases of B-LBL with C-MYC rearrangement, which overlapped features of B-LBL and Burkitt lymphoma (BL), including highly aggressive clinical presentation, lymphoblasts with precursor B-cell phenotype and C-MYC rearrangement; the combination treatment of the mature B-NHL protocol and ALL-type protocol may be appropriate for this rare entity, and more studies are required to identify an adequate therapeutic strategy.
Authors
- Xueqing Bai
- Yanlong Duan (ORCID: https://orcid.org/0000-0003-2048-6397)
- Xueliang Yang
- Chunju Zhou (ORCID: https://orcid.org/0009-0000-7196-5051)
- Meng Zhang (ORCID: https://orcid.org/0000-0003-1852-0322)
- Shuang Huang (ORCID: https://orcid.org/0000-0002-9851-2447)
- Ling Jin (ORCID: https://orcid.org/0009-0005-3005-7870)
- Ningning Zhang (ORCID: https://orcid.org/0000-0003-4070-9658)
Institutions
- Capital Medical University (CN)
- Beijing Children’s Hospital (CN)
- Ministry of Education and Child Care (CA)
Publication Details
- Journal
- Annals of Hematology
- Published
- 2025-04-04
- DOI
- https://doi.org/10.1007/s00277-025-06330-0
- Citations
- 1
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 1.88