A High-Throughput, Three-Dimensional Multiple Myeloma Model Recapitulating Tumor-Stroma Interactions for CAR-Immune Cell-Mediated Cytotoxicity Assay.
Our established 3D spheroid model, which partially recapitulates the complex TME with immunosuppressive environment, is suitable for high-throughput screening of CAR-immune cytotoxicity and could be important in accelerating immuno-oncology drug discovery for MM since there is a pressing need to establish innovative CAR-immune cells.
Authors
- Sasitorn Rungarunlert (ORCID: https://orcid.org/0000-0001-5500-1295)
- Surapol Issaragrisil (ORCID: https://orcid.org/0000-0002-8924-0646)
- Napachai Rodboon
- Montira Janan
- Sudjit Luanpitpong (ORCID: https://orcid.org/0000-0002-1639-4935)
- Jirarat Poohadsuan (ORCID: https://orcid.org/0000-0001-5528-5697)
- Parinya Samart
Institutions
- Siriraj Hospital (TH)
- Mahidol University (TH)
- Bangkok Hospital (TH)
Publication Details
- Journal
- PubMed
- Published
- 2025-01-01
- DOI
- https://doi.org/10.2147/itt.s503984
- Citations
- 3
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 4.08