Neurofilament Light Chain Levels, Skeletal Muscle Loss, and Nutritional Decline: Key Prognostic Factors in Amyotrophic Lateral Sclerosis
Our findings indicate that poor nutritional status, particularly reduced skeletal muscle mass-both independently and in combination with fat mass loss-is associated with elevated NfL levels and faster ALS progression. NfL, combined with nutritional parameters, could serve as a valuable biomarker for disease severity. Further research is warranted to clarify the role of skeletal muscle abnormalities in ALS progression.
Authors
- Giovanni Federico (ORCID: https://orcid.org/0000-0003-4604-5426)
- Eugenio Parati (ORCID: https://orcid.org/0000-0001-5020-6523)
- Aı́da Zulueta (ORCID: https://orcid.org/0000-0001-8295-6847)
- Domenico Azzolino (ORCID: https://orcid.org/0000-0002-4910-7373)
- Paolo Magni (ORCID: https://orcid.org/0000-0002-2254-8881)
- Tiziano Lucchi (ORCID: https://orcid.org/0000-0002-2029-5120)
- Rachele Piras (ORCID: https://orcid.org/0009-0000-8095-1014)
- Riccardo Sideri (ORCID: https://orcid.org/0000-0002-3261-8062)
- Cecilia Garrè
- Paola Mariani (ORCID: https://orcid.org/0000-0001-5675-0140)
Institutions
- University of Milan (IT)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Istituti Clinici Scientifici Maugeri (IT)
- MultiMedica (IT)
Publication Details
- Journal
- Muscle & Nerve
- Published
- 2025-04-04
- DOI
- https://doi.org/10.1002/mus.28407
- Citations
- 3
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 4.17
Funders
- Ministero della Salute