Population‐Based Versus Hospital‐Based Data in Amyotrophic Lateral Sclerosis—A Factor to Consider?
The observed differences likely indicate a selection bias in hospital-based data, which may be attributed, among others, to the willingness to travel large distances to a specialized center, the desire to participate in clinical studies, and the attitude toward life-prolonging measures. These differences must be considered when interpreting and generalizing study results from hospital-based populations.
Authors
- Albert C. Ludolph (ORCID: https://orcid.org/0000-0002-5401-0904)
- A. Lindner
- David A. Brenner (ORCID: https://orcid.org/0000-0003-2573-525X)
- Silke Dempewolf
- Raphael S. Peter (ORCID: https://orcid.org/0000-0003-4310-9500)
- Hansjörg Bäzner (ORCID: https://orcid.org/0000-0001-8944-8239)
- Angela Rosenbohm (ORCID: https://orcid.org/0000-0001-9700-0338)
- Jens Dreyhaupt (ORCID: https://orcid.org/0000-0001-8057-161X)
- Christian Opherk
- Gabriele Nagel (ORCID: https://orcid.org/0000-0001-6185-8535)
- Simon Witzel (ORCID: https://orcid.org/0000-0003-1841-954X)
- Maximilian Wiesenfarth (ORCID: https://orcid.org/0009-0004-0187-5973)
- Özlem Parlak
- Zeynep Elmas
- Joachim Schuster (ORCID: https://orcid.org/0000-0002-9577-9541)
- Katharina Althaus (ORCID: https://orcid.org/0000-0002-9004-4335)
- Wolfgang Ruf (ORCID: https://orcid.org/0000-0002-8105-6123)
- Johannes Dorst (ORCID: https://orcid.org/0000-0001-6352-0909)
- Ulrike Weiland (ORCID: https://orcid.org/0009-0001-7944-6819)
- Axel Boertlein
- Christian Foerch (ORCID: https://orcid.org/0000-0002-3770-7857)
- Deborah Wernecke (ORCID: https://orcid.org/0000-0002-6934-9257)
- Martin Hecht (ORCID: https://orcid.org/0000-0003-4959-5570)
- Christine Herrmann
- Andreas Köhler
- Monika Clauer‐Bredt
Institutions
- Universität Ulm (DE)
- German Center for Neurodegenerative Diseases (DE)
- Katharinenhospital (DE)
- Sensor-Technik Wiedemann (Germany) (DE)
- Marienhospital Stuttgart (DE)
- Zimmer Biomet (Germany) (DE)
- Klinikum Ludwigsburg (DE)
- SLK-Kliniken Heilbronn (DE)
Publication Details
- Journal
- European Journal of Neurology
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1111/ene.70137
- Citations
- 2
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 2.78
Funders
- Deutsche Forschungsgemeinschaft