Concomitant use of metformin and proton pump inhibitors increases vitamin <scp>B12</scp> deficiency risk in type 2 diabetes

A significant association between the concurrent use of metformin and PPI and an increased risk of vitamin B12 deficiency was found, highlighting the need to carefully monitor the symptoms associated with vitamin B12 deficiency and regularly assess vitamin B12 levels when considering the concomitant use of PPI and metformin.

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Publication Details

Journal
Journal of Diabetes Investigation
Published
2025-04-04
DOI
https://doi.org/10.1111/jdi.70037
Citations
6
Primary Topic
Folate and B Vitamins Research
Type
article
Field-Weighted Citation Impact
10.01

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article

Concomitant use of metformin and proton pump inhibitors increases vitamin B12 deficiency risk in type 2 diabetes

Choungwon Jung, Soyoung Park, Hyunah Kim
6 citations
Journal of Diabetes Investigation
Folate and B Vitamins Research
10.01
article

Concomitant use of metformin and proton pump inhibitors increases vitamin B12 deficiency risk in type 2 diabetes

Choungwon Jung, Soyoung Park, Hyunah Kim
article en
6 citations

Abstract

A significant association between the concurrent use of metformin and PPI and an increased risk of vitamin B12 deficiency was found, highlighting the need to carefully monitor the symptoms associated with vitamin B12 deficiency and regularly assess vitamin B12 levels when considering the concomitant use of PPI and metformin.

Journal of Diabetes InvestigationVol. 16(6)
Sookmyung Women's University (KR)
National Research Foundation, National Health Insurance Service, National Research Foundation of Korea, Ministry of Science and ICT, South Korea
Good health and well-being
Openalex Percentile: Top 2%
Folate and B Vitamins Research
10.01
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