Neuropsychological outcomes of hippocampus‐sparing anterior temporal lobectomy versus stereotactic laser amygdalohippocampectomy in language‐dominant temporal lobe epilepsy
In language-dominant TLE, SLAH demonstrated comparable seizure outcomes and superior verbal memory retention compared to HSATL, albeit with greater letter fluency impairment. Preliminary findings challenge prioritizing hippocampal preservation for verbal memory function, suggesting potential cognitive advantages with SLAH specifically targeting mesial structures while maximally preserving cortical structures and white matter tracts critical for language networks. However, this intervention may negatively impact letter fluency, suggesting careful preoperative screening and discussion.
Authors
- Long Di
- Mike R. Schoenberg (ORCID: https://orcid.org/0000-0003-1355-3651)
- Ushtar Amin
- Keaton Piper (ORCID: https://orcid.org/0000-0002-5051-8866)
- Fernando Ĺ. Vale (ORCID: https://orcid.org/0000-0002-0830-5445)
- Adam Alayli (ORCID: https://orcid.org/0000-0002-6986-788X)
- Yarema Bezchlibnyk (ORCID: https://orcid.org/0000-0002-7509-1723)
- Molly Monsour (ORCID: https://orcid.org/0000-0001-9801-7465)
- Joseph J. Boscarino (ORCID: https://orcid.org/0000-0001-6919-4593)
- Zeegan George (ORCID: https://orcid.org/0000-0001-6236-6460)
- Elliot G. Neal (ORCID: https://orcid.org/0000-0002-5012-5704)
- Samantha J. Schimmel (ORCID: https://orcid.org/0000-0001-9860-8820)
Institutions
- University of Miami (US)
- Augusta University (US)
- University of South Florida (US)
- James A. Haley Veterans' Hospital (US)
Publication Details
- Journal
- Epilepsia
- Published
- 2025-04-04
- DOI
- https://doi.org/10.1111/epi.18388
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00