The tumour–stroma ratio as predictive aid towards a biopsy‐based treatment strategy in rectal carcinoma
Biopsy-scored TSR can predict neoadjuvant therapy efficacy, as RC patients with stroma-high biopsies show less major response. However, patient survival is multifactorial, although response is an important predictor, influenced by TSR. Scoring TSR on RC biopsy material is a reliable histological parameter, implementation of which in treatment guidelines could improve upfront selection for a watch-and-wait strategy.
Authors
- Meaghan Polack (ORCID: https://orcid.org/0000-0001-7980-7533)
- Koen Peeters (ORCID: https://orcid.org/0000-0002-9332-1334)
- Gabi W. van Pelt (ORCID: https://orcid.org/0000-0003-1449-7348)
- J. Han van Krieken (ORCID: https://orcid.org/0000-0002-8105-0450)
- Rob A.�E.�M. Tollenaar (ORCID: https://orcid.org/0000-0002-6831-6082)
- Stijn Crobach (ORCID: https://orcid.org/0000-0002-1289-4406)
- Irıs D. Nagtegaal (ORCID: https://orcid.org/0000-0003-0887-4127)
- Elma Meershoek‐Klein Kranenbarg (ORCID: https://orcid.org/0000-0002-1750-2221)
- Hein Putter (ORCID: https://orcid.org/0000-0001-5395-1422)
- Annet G.H. Roodvoets (ORCID: https://orcid.org/0000-0002-0412-1075)
- Wilma E. Mesker (ORCID: https://orcid.org/0000-0001-5533-4778)
- Davita H van den Heuvel
Institutions
- Radboud University Nijmegen (NL)
- Leiden University Medical Center (NL)
- Radboud University Medical Center (NL)
Publication Details
- Journal
- Histopathology
- Published
- 2025-04-04
- DOI
- https://doi.org/10.1111/his.15423
- Primary Topic
- Colorectal Cancer Surgical Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Cancerfonden
- Ministerio de Economía y Competitividad
- Leids Universitair Medisch Centrum
- Radboud Universitair Medisch Centrum
- Spanish Clinical Research Network