Deficiency of the Synaptic Adhesion Protein Leucine‐Rich Repeat Transmembrane Protein 4 Like 1 Affects Anxiety and Aggression in Zebrafish
These findings suggest that LRRTMs may have functions beyond their established role in excitatory synapse development, such as the regulation of neurotransmission and behavior. Targeting LRRTM4 therapeutically may thus be an interesting novel approach to alleviate excessive aggression or anxiety associated with a number of neuropsychiatric conditions.
Authors
- Guido Petracco
- Agnes A. Mooslechner (ORCID: https://orcid.org/0000-0002-3266-3293)
- Thomas Bärnthaler (ORCID: https://orcid.org/0000-0002-4988-3700)
- Florian Reichmann (ORCID: https://orcid.org/0000-0002-5833-3698)
- Eva Tatzl
- Giovanny Rodriguez Blanco (ORCID: https://orcid.org/0000-0002-7154-7244)
- Marco Balasso
- Isabella Faimann (ORCID: https://orcid.org/0009-0001-5897-3791)
Institutions
- Medical University of Graz (AT)
- BioTechMed-Graz (AT)
Publication Details
- Journal
- Acta Physiologica
- Published
- 2025-04-04
- DOI
- https://doi.org/10.1111/apha.70042
- Citations
- 4
- Primary Topic
- Zebrafish Biomedical Research Applications
- Type
- article
- Field-Weighted Citation Impact
- 4.61
Funders
- Austrian Science Fund