Breast reconstruction and neoadjuvant radiotherapy (BRENAR) – study protocol for a multicenter, prospective, single-arm pilot study
The primary outcome of this pilot study is to provide further evidence to determine whether NART is a viable alternative to PMRT in terms of complication rates when combined with immediate breast reconstruction. The secondary outcomes will enhance our understanding of patients' HR-QoL and cosmetic outcomes. If NART proves to be a safe alternative, this pilot study will lay the foundation for a national multicenter randomized controlled trial to evaluate long-term HR-QoL and oncological outcomes.
Authors
- Liesbeth Boersma (ORCID: https://orcid.org/0000-0001-9173-279X)
- Patrick I. Ferdinandus
- Henk J. Coert
- Danny A. Young‐Afat (ORCID: https://orcid.org/0000-0001-9628-5896)
- Arjen J. Witkamp (ORCID: https://orcid.org/0000-0002-0313-8844)
- Desirée H J G van den Bongard
- Joeke M. Felderhof
- Susanne van der Velde (ORCID: https://orcid.org/0000-0003-0356-551X)
- Sophie H. Nelissen
- Liesbeth M. Veenendaal
- Annemiek Doeksen
- Erik Zonnevylle (ORCID: https://orcid.org/0009-0002-4146-9617)
- Jan Maerten Smit (ORCID: https://orcid.org/0000-0002-3028-0934)
- Femke van der Leij
- Wies Maarse
Institutions
- Maastricht University Medical Centre (NL)
- University Medical Center Utrecht (NL)
- Alexander Monro Ziekenhuis (NL)
- St. Antonius Ziekenhuis (NL)
- Amsterdam University Medical Centers (NL)
- Maastro Clinic (NL)
Publication Details
- Journal
- International Journal of Surgery Protocols
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1097/sp9.0000000000000036
- Citations
- 1
- Primary Topic
- Breast Cancer Treatment Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.94