Bilateral Breast Cancer with Clinical Response to Chemotherapy: A Case Report

Back ground: Breast cancer is the most common cancer among women counting about 125 per 100000 per year new case in United States and about 1.4milion new cases worldwide. In the last twenty years early diagnosis, neoadjuvant and adjuvant systemic treatment that targeted to specific molecular targets have significantly reduced the mortality from breast cancer. Distant metastasis accounts for the vast majority of deaths in patients with cancer. Breast cancer exhibits a distinct metastatic pattern commonly involving bone, liver, lung, and brain. Breast cancer can be divided into different subtypes based on gene expression profiles, and different breast cancer subtypes show preference to distinct organ sites of metastasis. Bilateral breast cancer (BBC) is rare and is associated with unfavorable prognosis. riple-negative breast cancer (TNBC) has been associated with a more aggressive histology, poorer prognosis, and no responsiveness to hormone therapy. It is imperative that cancer research identify factors that drive disparities and focus on prevention. We report A case of metastatic bilateral breast cancers, A 58-year-old female presented with bilateral breast masses of 8-years duration. On examination. she had bilateral fungated breast masses, which were hard, mobile, and irregular. On the right side, there was skin tethering and palpable axillary lymph nodes. Ultrasound examination showed a heterogeneous, irregular, ill-defined, mass-like lesion, seen in the upper outer quadrant of the right breast along with a hypoechoic. irregular mass 12*13mm in the upper outer quadrant of the left breast. FNA showed bilateral invasive ductal carcinoma. Right axillary lymph nodes were positive for adenocarcinoma. She received 4 sessions of NACT which was followed by right-side mastectomy with axillary lymph node dissection and left-side mastectomy with sentinel lymph node biopsy.