Tobacco smoke exposure is a driver of altered oxidative stress response and immunity in head and neck cancer
The cigarette smoke exposome is a potent activator of the Nrf2 pathway and appears to be the primary trigger for a tripartite phenotype of aggressive HNSCC consisting of: (1) reduced chemotherapy sensitivity, (2) enhanced metastatic potential and (3) suppressed anti-tumor immunity.
Authors
- William Henry Hudson (ORCID: https://orcid.org/0000-0002-2513-1213)
- Keenan Ernste (ORCID: https://orcid.org/0000-0002-2988-6429)
- Lama Abdurrahman
- Nagireddy Putluri (ORCID: https://orcid.org/0000-0003-4488-7400)
- Heath Devin Skinner (ORCID: https://orcid.org/0000-0003-1836-151X)
- Vlad C. Sandulache (ORCID: https://orcid.org/0000-0002-9205-385X)
- Antrix Jain (ORCID: https://orcid.org/0000-0002-2815-3645)
- William K. Decker (ORCID: https://orcid.org/0000-0003-0992-5838)
- Jonathan Vazquez‐Perez (ORCID: https://orcid.org/0000-0002-6750-3468)
- Vasanta Putluri (ORCID: https://orcid.org/0000-0001-7943-2209)
- Francis Essien (ORCID: https://orcid.org/0000-0001-5337-2463)
- Rutulkumar Patel (ORCID: https://orcid.org/0000-0001-6652-6070)
- Farrah Kheradmand (ORCID: https://orcid.org/0000-0001-5343-103X)
- Pedram Yadollahi (ORCID: https://orcid.org/0009-0004-3971-5086)
- Cristian Coarfa (ORCID: https://orcid.org/0000-0002-4183-4939)
- Abu Hena Mostafa Kamal (ORCID: https://orcid.org/0000-0001-6750-0729)
- Karthik Reddy Kami Reddy (ORCID: https://orcid.org/0000-0002-3288-394X)
- Jeffrey N. Myers (ORCID: https://orcid.org/0000-0003-4767-3408)
- Chandrashekar R. Ambati (ORCID: https://orcid.org/0000-0001-5413-6745)
- Maria Elisa Ruiz Echartea
- Abdullah A. Osman (ORCID: https://orcid.org/0000-0002-6320-6255)
- Stephen Y. Lai (ORCID: https://orcid.org/0000-0001-8301-7286)
- Anna Malovannaya
- Mitchell J. Frederick (ORCID: https://orcid.org/0000-0002-0932-8809)
- Kwang‐Won Lee (ORCID: https://orcid.org/0000-0001-5326-469X)
- Li Yang (ORCID: https://orcid.org/0000-0001-7609-0960)
- Akshar Trivedi
Institutions
- Michael E. DeBakey VA Medical Center (US)
- The University of Texas MD Anderson Cancer Center (US)
- University of Pittsburgh (US)
- Baylor College of Medicine (US)
- Children's Cancer Center (US)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-04-05
- DOI
- https://doi.org/10.1186/s12967-025-06258-z
- Citations
- 6
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 4.84
Funders
- U.S. Department of Veterans Affairs
- Cancer Prevention and Research Institute of Texas
- Dan L. Duncan Cancer Center, Baylor College of Medicine
- National Institutes of Health
- National Cancer Institute
- National Institute of Allergy and Infectious Diseases
- National Institute of Dental and Craniofacial Research
- Office of Extramural Research, National Institutes of Health