Identification of FDFT1 and PGRMC1 as New Biomarkers in Nonalcoholic Steatohepatitis (NASH)-Related Hepatocellular Carcinoma by Deep Learning
In conclusion, FDFT1 and PGRMC1 are key enzymes in the cholesterol synthesis pathway, our study validates the important role of cholesterol metabolism in NAFLD from another perspective, implying they may be new prognostic and diagnostic markers for NASH-HCC.
Authors
- Ping Yao (ORCID: https://orcid.org/0000-0002-0196-4843)
- Zhentao Yu (ORCID: https://orcid.org/0000-0002-5785-8492)
- Qiang Zhu (ORCID: https://orcid.org/0000-0002-5843-9724)
- Yang Liu (ORCID: https://orcid.org/0000-0002-5221-7725)
- Tiantian Liu (ORCID: https://orcid.org/0000-0001-9377-9938)
- Yongshuai Wang
- Qiqi Liu (ORCID: https://orcid.org/0000-0002-1534-0919)
- Yinuo Yang (ORCID: https://orcid.org/0000-0003-1278-3711)
- Yuemin Feng (ORCID: https://orcid.org/0000-0003-3793-3237)
- Shuhang Wei
Institutions
- Xinjiang Medical University (CN)
- Shandong University (CN)
- First Affiliated Hospital of Xinjiang Medical University (CN)
- Shandong Provincial Hospital (CN)
- Shandong First Medical University (CN)
- Shandong University of Science and Technology (CN)
Publication Details
- Journal
- Journal of Hepatocellular Carcinoma
- Published
- 2025-04-01
- DOI
- https://doi.org/10.2147/jhc.s505752
- Citations
- 3
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.06