Efficient one-pot radiosynthesis of the 11C-labeled aquaporin-4 inhibitor TGN-020
[<sup>11</sup>C]TGN-020 with high A<sub>m</sub> was obtained in reproducible radiochemical yield. Overall, the proposed optimization process for the radiosynthesis of [<sup>11</sup>C]TGN-020 can facilitate its application as a PET radiopharmaceutical for clinical use.
Authors
- Hironaka Igarashi (ORCID: https://orcid.org/0000-0003-1663-5564)
- Tomoteru Yamasaki (ORCID: https://orcid.org/0000-0001-7773-3665)
- Maiko Ono
- Yusuke Kurihara
- Yukimi Nakamura
- Yuhei Takado (ORCID: https://orcid.org/0000-0001-7484-8424)
- Nobuki Nengaki
- Katsushi Kumata
- Kazunori Kawamura (ORCID: https://orcid.org/0000-0001-6786-678X)
- Masanao Ogawa
- Ming-Rong Zhang
Institutions
- Japan Proton Accelerator Research Complex (JP)
- National Institutes for Quantum Science and Technology (JP)
- Niigata University (JP)
Publication Details
- Journal
- EJNMMI Radiopharmacy and Chemistry
- Published
- 2025-04-05
- DOI
- https://doi.org/10.1186/s41181-025-00338-7
- Citations
- 2
- Primary Topic
- Ion Transport and Channel Regulation
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Japan Agency for Medical Research and Development
- Ministry of Education, Culture, Sports, Science and Technology
- Japan Society for the Promotion of Science
- Moonshot Research and Development Program