Prognostic Implication of t(1;19) in Pediatric Pre-B Acute Lymphoblastic Leukemia: A Nationwide Study

Introduction: Recurrent translocation t(1;19) (q23;p13) describes a unique cytogenetic group of childhood B-cell acute lymphoblastic leukemia (ALL).Historically, t(1;19)(q23;p13.3)has been associated with poor outcomes.However, recent data suggests that currently intensified treatments have overcome this dismal prognosis.We conducted this study to understand this type of translocation in our population.From January 1999 until May 2020, 44 children with t(1;19) were identified by cytogenetics analysis during chart review.Methodology: Cytogenetics (CG) testing results (Karyotype and/or FISH) were retrieved from the medical files on 37/44 patients.Results: Of the 37 patients with Cytogenetics results, a total of 12 patients were found to have t(1;19) (q23;p13.3)as the only detectable genetic change, 13 patients were presented with t(1;19)(q23;p13.3)plus further chromosomal rearrangement (Table 1), 12 patients were presented with a variation involving t(1;19)(q23;p13.3)with or without additional chromosomes rearrangement.