Improving the diagnostic performance of contrast-enhanced mammography through lesion conspicuity and enhancement quantification
Question Quantifying lesion enhancement conspicuity on contrast-enhanced mammography (CEM) has demonstrated potential in differentiating malignancy from benign lesions and BPE. Finding Contrast from the early recombined view (CEearly) performed better in discriminating malignant from benign lesions and BPE, with 90% specificity for BPE vs cancers. Clinical relevance Conspicuity and quantification of lesion enhancement on CEM can improve the specificity and overall diagnostic performance of CEM in cancer detection. Implementation of conspicuity thresholds in routine CEM interpretation could potentially reduce unnecessary recalls and benign biopsies.
Authors
- Thiemo J. A. van Nijnatten (ORCID: https://orcid.org/0000-0002-6431-3538)
- Roido Manavaki (ORCID: https://orcid.org/0000-0002-4384-6626)
- Vasiliki Papalouka (ORCID: https://orcid.org/0000-0002-3226-0224)
- Fleur Kilburn‐Toppin (ORCID: https://orcid.org/0000-0002-4234-3824)
- Nuala Healy (ORCID: https://orcid.org/0000-0002-0620-6056)
- Fiona J. Gilbert (ORCID: https://orcid.org/0000-0002-0124-9962)
- Iris Allajbeu
- Elisabetta Giannotti (ORCID: https://orcid.org/0000-0001-6924-9822)
- Ioana Bene (ORCID: https://orcid.org/0000-0003-2227-9981)
- Nicholas Roy Payne (ORCID: https://orcid.org/0000-0002-0492-971X)
- Muzna Nanaa (ORCID: https://orcid.org/0000-0001-7884-456X)
Institutions
- University of Medicine Tirana (AL)
- St Bartholomew's Hospital (GB)
- Royal College of Surgeons in Ireland (IE)
- Iuliu Hațieganu University of Medicine and Pharmacy (RO)
- University of Cambridge (GB)
- Maastricht University Medical Centre (NL)
- Beaumont Hospital (IE)
- Cambridge University Hospitals NHS Foundation Trust (GB)
- Maastricht University (NL)
- Cambridge School (PT)
- Addenbrooke's Hospital (GB)
Publication Details
- Journal
- European Radiology
- Published
- 2025-04-03
- DOI
- https://doi.org/10.1007/s00330-025-11501-8
- Citations
- 3
- Primary Topic
- MRI in cancer diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 4.08
Funders
- National Institute for Health Research Health Protection Research Unit
- Cancer Research UK