Distinct Luteinization Profiles of Cultured Human Granulosa Cells From Small Antral and Preovulatory Follicles
This study uniquely demonstrates that unstimulated follicular granulosa cells undergo a gradual, intrinsic luteinization process, independent of external hormonal triggers. In contrast, granulosa-lutein cells are already highly luteinized upon aspiration. These findings challenge conventional views on luteinization and highlight intrinsic cellular programming as a key driver, offering new insights into ovarian physiology and potential therapeutic targets for reproductive disorders.
Authors
- Jane Alrø Bøtkjær (ORCID: https://orcid.org/0000-0002-7114-0970)
- Cristina Subiran Adrados (ORCID: https://orcid.org/0000-0002-3002-9125)
- Kirsten Tryde Macklon (ORCID: https://orcid.org/0000-0001-8830-513X)
- Emmanuel C. Opara (ORCID: https://orcid.org/0000-0002-3486-1453)
- Lea Bejstrup Jensen (ORCID: https://orcid.org/0009-0001-3231-435X)
- Sivanandane Sittadjody (ORCID: https://orcid.org/0000-0003-1990-3640)
- Peter Sørensen (ORCID: https://orcid.org/0000-0003-3425-3690)
- Jesús Cadenas (ORCID: https://orcid.org/0000-0001-8164-3697)
- Stine Gry Kristensen (ORCID: https://orcid.org/0000-0003-1194-8393)
- Anette Tønnes Pedersen
Institutions
- Forest Institute (US)
- University of Copenhagen (DK)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
- Wake Forest University (US)
Publication Details
- Journal
- The Journal of Clinical Endocrinology & Metabolism
- Published
- 2025-04-05
- DOI
- https://doi.org/10.1210/clinem/dgaf218
- Citations
- 3
- Primary Topic
- Reproductive Biology and Fertility
- Type
- article
- Field-Weighted Citation Impact
- 5.64
Funders
- Novo Nordisk
- Novo Nordisk Fonden
- Simon Spies Fonden