Si-ITGA6-Loaded Liposomes Inhibit Capsule Fibrosis via the FAK/PI3K/Akt Signaling Pathway in Adhesive Capsulitis of Shoulder
This research elucidated that ITGA6 was upregulated in the capsules of patients with ACS and is capable of significantly activating fibroblasts through the FAK/PI3K/Akt signaling pathway. By targeting ITGA6, si-ITGA6-loaded liposomes could effectively attenuate capsule fibrosis. In this study, we identified ITGA6 as a key regulator in ACS and demonstrated that targeting ITGA6 with siRNA-loaded liposomes effectively attenuated capsule fibrosis and improved joint mobility, offering a promising approach for targeted therapy of ACS.
Authors
- Weihao Jiang
- Yaying Sun (ORCID: https://orcid.org/0000-0001-5457-6046)
- Chengqing Yi (ORCID: https://orcid.org/0000-0002-1103-456X)
- Beijie Qi (ORCID: https://orcid.org/0000-0002-4041-0050)
- Qi Wang (ORCID: https://orcid.org/0000-0003-3594-2244)
- Qian Wang (ORCID: https://orcid.org/0009-0000-6276-9120)
- Chenxu Wang (ORCID: https://orcid.org/0000-0002-9539-5046)
- Dejian Li (ORCID: https://orcid.org/0000-0003-3537-9180)
- Shi Shi
Institutions
- Shanghai Jiao Tong University (CN)
- Fudan University (CN)
- Pudong Medical Center (CN)
- Shanghai First People's Hospital (CN)
- First Affiliated Hospital of Henan University (CN)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2025-04-01
- DOI
- https://doi.org/10.2147/ijn.s501561
- Citations
- 2
- Primary Topic
- Shoulder Injury and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.01