Two routes for tyrosol production by metabolic engineering of Corynebacterium glutamicum
This study demonstrates the potential of endotoxin-free C. glutamicum as production host for the L-tyrosine-derived product tyrosol. Due to its L-arogenate pathway for L-tyrosine synthesis, the unstable 4-OH-phenylpyruvate could be excluded as intermediate in the Tdc-Tyo pathway, outcompeting the most often utilized production route via phenylpyruvate decarboxylases.
Authors
- Nora Junker (ORCID: https://orcid.org/0009-0004-6850-1167)
- Sara-Sophie Poethe (ORCID: https://orcid.org/0000-0001-6697-7971)
- Volker F. Wendisch (ORCID: https://orcid.org/0000-0003-3473-0012)
Institutions
- Bielefeld University (DE)
Publication Details
- Journal
- Biotechnology for Biofuels and Bioproducts
- Published
- 2025-04-05
- DOI
- https://doi.org/10.1186/s13068-025-02641-6
- Citations
- 7
- Primary Topic
- Microbial Metabolic Engineering and Bioproduction
- Type
- article
- Field-Weighted Citation Impact
- 5.64
Funders
- Universität Bielefeld