Clinical implement of Probe‐Capture Metagenomics in sepsis patients: A multicentre and prospective study
Probe-Capture Metagenome had a significantly higher positive rate than blood culture (51.6% vs. 17.4%, p < .001). Combining blood culture and RT-PCR results, Probe-Capture Metagenome achieved a consistency rate of 91.8%. Antibiotics were adjusted in 34.8% of patients based on Probe-Capture Metagenome results, and 22.3% of patients experienced a more than 2-point decrease in SOFA score.
Authors
- Ran Teng (ORCID: https://orcid.org/0009-0008-6416-5943)
- Weiqi Zeng (ORCID: https://orcid.org/0000-0002-6448-1726)
- Haibo Qiu (ORCID: https://orcid.org/0000-0001-9360-6682)
- Xing Cai (ORCID: https://orcid.org/0000-0003-3706-4414)
- Ling Liu (ORCID: https://orcid.org/0000-0002-4347-4252)
- Chang Shu (ORCID: https://orcid.org/0000-0003-0825-0883)
- Qin Sun (ORCID: https://orcid.org/0000-0001-7888-3251)
- Xu Mei (ORCID: https://orcid.org/0009-0005-4536-8575)
- Quan Cao (ORCID: https://orcid.org/0000-0002-1566-8850)
- Qiankun Shi
- Junyi Zhang (ORCID: https://orcid.org/0009-0000-1534-439X)
- Bin Yang (ORCID: https://orcid.org/0000-0001-6180-7412)
- Bingxue Hu (ORCID: https://orcid.org/0000-0001-9116-6249)
- Yun Liu (ORCID: https://orcid.org/0000-0003-4377-1211)
Institutions
- Zhongda Hospital Southeast University (CN)
- Vision Medicals (China) (CN)
- Northern Jiangsu People's Hospital (CN)
- Jiangsu Province Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/ctm2.70297
- Citations
- 6
- Primary Topic
- Bacterial Identification and Susceptibility Testing
- Type
- article
- Field-Weighted Citation Impact
- 7.91
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China