Circadian rhythm disturbances in Alzheimer’s disease: insights from plaque-free and plaque-burdened stages in APPSWE/PS1dE9 mice
These findings revealed that circadian rhythm disturbances in AD mice preceded Aβ deposition. The circadian rhythm disturbances observed in the early AD might be attributed to the abnormal expression of core clock genes in the brain regions involved in circadian rhythm regulation.
Authors
- Weidong Le (ORCID: https://orcid.org/0000-0001-7459-2705)
- Long Niu
- Lulu Tian (ORCID: https://orcid.org/0000-0001-5820-0337)
- Yiying Hu
- Cheng Cheng (ORCID: https://orcid.org/0000-0002-9895-6240)
- Song Li (ORCID: https://orcid.org/0000-0003-2713-9136)
- Huijia Yang
Institutions
- Dalian Medical University (CN)
- Changzhi Medical College (CN)
- First Affiliated Hospital of Dalian Medical University (CN)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2025-04-05
- DOI
- https://doi.org/10.1186/s13195-025-01724-8
- Citations
- 11
- Primary Topic
- Circadian rhythm and melatonin
- Type
- article
- Field-Weighted Citation Impact
- 10.06
Funders
- National Natural Science Foundation of China