Unveiling the Novel Anti - Tumor Potential of Digitonin, a Steroidal Saponin, in Gastric Cancer: A Network Pharmacology and Experimental Validation Study
Digitonin serves as a promising multi-target therapeutic agent for GC. This study underscores the potential of combining network pharmacology with traditional Chinese medicine to identify novel therapeutic targets and develop effective anti-cancer strategies. In addition, these findings suggest that digitonin could be a promising candidate for future clinical trials in GC treatment.
Authors
- Dongdong Lu (ORCID: https://orcid.org/0000-0003-0983-7213)
- Chunyan Weng (ORCID: https://orcid.org/0000-0003-2469-4628)
- Liyue Huang
Institutions
- Zhejiang Chinese Medical University (CN)
- Ningbo No. 2 Hospital (CN)
- Ningbo No.6 Hospital (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2025-04-01
- DOI
- https://doi.org/10.2147/dddt.s504671
- Citations
- 5
- Primary Topic
- Phytochemistry and Bioactive Compounds
- Type
- article
- Field-Weighted Citation Impact
- 2.99