Impact of Propranolol and Psychologically Informed Intervention on Pain Sensitivity: Secondary Analysis from the Biopsychosocial Influence on Shoulder Pain Preclinical Randomized Trial
Results indicated no statistically reliable changes in pain sensitivity when considering matched vs unmatched treatment groups. Caution is needed in this interpretation given that the trial was not powered to specifically identify these differences. Exploratory analysis of interactions among ethnic/racial and gender identities by treatment, however, showed the potential for differential effects for specific pain sensitivity measures. Significant interactions across modalities suggest analysis of higher order interactions/intersectionality could be of great interest for testing efficacy of personalized interventions in future trials.
Authors
- Roland Staud (ORCID: https://orcid.org/0000-0002-1317-2368)
- Mark D. Bishop (ORCID: https://orcid.org/0000-0002-2832-6913)
- Corey B. Simon (ORCID: https://orcid.org/0000-0002-6121-9511)
- Steven Z. George (ORCID: https://orcid.org/0000-0003-4988-9421)
- Paul A. Borsa (ORCID: https://orcid.org/0000-0001-5536-2541)
- Roger Benton Fillingim (ORCID: https://orcid.org/0000-0002-7699-8183)
- Margaret R. Wallace (ORCID: https://orcid.org/0000-0002-5202-8895)
- Yanan Huo (ORCID: https://orcid.org/0000-0002-9774-6698)
- Samuel S. Wu
Institutions
- Duke University (US)
- University of Florida (US)
- Clinical Research Institute (US)
- Gilead Sciences (United States) (US)
- Duke University Hospital (US)
Publication Details
- Journal
- Journal of Pain Research
- Published
- 2025-04-01
- DOI
- https://doi.org/10.2147/jpr.s500140
- Citations
- 1
- Primary Topic
- Shoulder Injury and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.01