Timing of pharmacological venous thromboembolism prophylaxis after firearm-related penetrating brain injury
Among patients with firearm-related PBI, earlier pharmacological prophylaxis was associated with decreased odds of VTE. However, earlier prophylaxis was also associated with late neurosurgical decompression among patients who underwent intracranial monitor/drain placement or no intervention, an effect not observed for patients who underwent early craniotomy/craniectomy. These findings suggest that while early prophylaxis should be prioritized, prospective study is needed to clarify safe timing of initiation in different patient groups.
Authors
- James Byrne (ORCID: https://orcid.org/0000-0003-3517-5110)
- Kathleen R. Ran (ORCID: https://orcid.org/0000-0001-5573-7534)
- Wuyang Yang (ORCID: https://orcid.org/0000-0001-5934-7795)
- Debraj Mukherjee (ORCID: https://orcid.org/0000-0002-5403-8237)
- Megan Parker (ORCID: https://orcid.org/0000-0002-1096-9662)
- Christopher D. Witiw (ORCID: https://orcid.org/0000-0002-3999-7632)
- Caitlin W. Hicks (ORCID: https://orcid.org/0000-0001-7638-1936)
- Tej D. Azad (ORCID: https://orcid.org/0000-0001-7823-4294)
- Elliott Richard Haut (ORCID: https://orcid.org/0000-0001-7075-771X)
- Morgan Schellenberg (ORCID: https://orcid.org/0000-0001-5743-596X)
- Vikas N. Vattipally (ORCID: https://orcid.org/0009-0000-6920-2311)
- Jiaqi Liu (ORCID: https://orcid.org/0000-0003-2036-8200)
- Foad Kazemi (ORCID: https://orcid.org/0000-0001-5605-9042)
- Carlos Aguilera
Institutions
- St. Michael's Hospital (CA)
- University of British Columbia (CA)
- Johns Hopkins University (US)
- Georgetown University (US)
- Johns Hopkins Medicine (US)
- Los Angeles Medical Center (US)
- Johns Hopkins Hospital (US)
Publication Details
- Journal
- Journal of neurosurgery
- Published
- 2025-04-05
- DOI
- https://doi.org/10.3171/2024.12.jns242004
- Citations
- 1
- Primary Topic
- Trauma and Emergency Care Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.25