Efficacy of gemcitabine plus nab-paclitaxel in second-line treatment of metastatic pancreatic cancer
Despite numerous studies on second-line therapies in metastatic pancreatic cancer, there is no randomized study evaluating the efficacy of gemcitabine plus nab-paclitaxel as a second-line treatment. This study aims to examine the efficacy of gemcitabine plus nab-paclitaxel in second-line therapy. In this retrospective study, a total of 218 patients from 23 centers were included. The primary endpoint was progression-free survival (PFS), secondary endpoints included overall survival (OS), treatment efficacy based on ECOG performance status (PS), and tumor marker (CEA, CA 19 - 9) levels. In the second-line treatment with gemcitabine plus nab-paclitaxel, the median PFS was 5.1 months (95% CI, 5.6 to 7.1), and the median OS was 8.6 months (95% CI, 7.3 to 10.0). Median PFS was 6.6 months in patients with normal CEA levels compared to 4.4 months in patients with high CEA levels (P = 0.01). Median PFS was 6 months in patients with ECOG PS 0-1 compared to 3.8 months in patients with PS 2 (P < 0.01). This study demonstrates the contribution of gemcitabine plus nab-paclitaxel in both OS and PFS in second-line treatment of metastatic pancreatic cancer. It was found to be a good option especially for young patients with good ECOG PS.
Authors
- Oğur Karhan (ORCID: https://orcid.org/0000-0002-7140-8957)
- Mustafa Özgür Arıcı (ORCID: https://orcid.org/0000-0001-9821-6368)
- Hacer Demir (ORCID: https://orcid.org/0000-0003-1235-9363)
- Ahmet Ufuk Kömüroğlu (ORCID: https://orcid.org/0000-0002-0371-9251)
- Talat Aykut (ORCID: https://orcid.org/0000-0002-9614-0651)
- Mehmet Zeki Erdem (ORCID: https://orcid.org/0000-0001-5439-9473)
- Bilgin Demir (ORCID: https://orcid.org/0000-0003-4380-9419)
- Nargız Majidova (ORCID: https://orcid.org/0000-0002-2575-5819)
- Ali Alper Solmaz (ORCID: https://orcid.org/0000-0003-4696-1723)
- Yasin Sezgin (ORCID: https://orcid.org/0000-0003-4122-8389)
- Semiha Urvay (ORCID: https://orcid.org/0000-0002-0181-3842)
- Burcu Ulaş Kahya (ORCID: https://orcid.org/0000-0003-3661-9852)
- Abdurrahman Bicer
- İbrahim Aydın (ORCID: https://orcid.org/0000-0001-5850-4808)
- Sedat Yıldız (ORCID: https://orcid.org/0000-0002-7872-790X)
- İlkay Gültürk (ORCID: https://orcid.org/0000-0003-1998-3150)
- Mehmet Nuri Başer (ORCID: https://orcid.org/0000-0003-1809-5581)
- Muslih Ürün (ORCID: https://orcid.org/0000-0002-9883-3398)
- Yakup Ergün (ORCID: https://orcid.org/0000-0003-4784-6743)
- Mürsel Salı (ORCID: https://orcid.org/0009-0007-2079-3350)
- Mustafa Yıldırım (ORCID: https://orcid.org/0000-0002-4479-8136)
- Musa Barış Aykan (ORCID: https://orcid.org/0000-0001-7538-9119)
- Mehmet Naci Aldemir (ORCID: https://orcid.org/0000-0002-7931-9078)
- Halis Yerlikaya
- Mustafa Gürbüz (ORCID: https://orcid.org/0000-0001-7680-4142)
- Murat Araz (ORCID: https://orcid.org/0000-0002-4632-9501)
- Melike Özçelik (ORCID: https://orcid.org/0000-0003-0406-715X)
- Müge Sönmez
- Sezai Tunç (ORCID: https://orcid.org/0000-0002-4972-9367)
- Zuhat Urakçı (ORCID: https://orcid.org/0000-0003-3878-988X)
- Berrak Mermit Erçek (ORCID: https://orcid.org/0000-0003-1058-5500)
- Sinem Akbaş
- Serdar İleri (ORCID: https://orcid.org/0000-0002-3739-3528)
- Abdullah Sakin (ORCID: https://orcid.org/0000-0003-2538-8569)
- Hayati Arvas (ORCID: https://orcid.org/0000-0003-2215-5567)
- Savaş Gökçek (ORCID: https://orcid.org/0000-0001-5928-0447)
- Hicran Anık (ORCID: https://orcid.org/0009-0001-7992-4008)
- Mirmehdi Mehtıyev
- Nilüfer Avcı (ORCID: https://orcid.org/0000-0003-1094-5772)
- Esra Özen
- Mehmet Emin Kalender
- Ali Alkan
Institutions
- Sakarya University (TR)
- Van Yüzüncü Yıl Üniversitesi (TR)
- Dicle University (TR)
- Bursa Uludağ Üni̇versi̇tesi̇ (TR)
- Izmir University (TR)
- Koç University (TR)
- Bilkent University (TR)
- Dokuz Eylül University (TR)
- Fatih University Medical Faculty Hospital (TR)
- Gülhane Askerî Tıp Akademisi (TR)
- Necmettin Erbakan University (TR)
- Sivas State Hospital (TR)
- Ankara Onkoloji Eğitim ve Araştırma Hastanesi (TR)
- Ümraniye Eğitim ve Araştırma Hastanesi (TR)
- Education Training And Research (US)
- Şanlıurfa Mehmet Akif İnan Eğitim ve Araştırma Hastanesi (TR)
- Diyarbakır Gazi Yaşargil Eğitim ve Araştırma Hastanesi (TR)
- Istanbul Eye Hospital (TR)
- Afyon Kocatepe University (TR)
- Istanbul University (TR)
- Marmara University (TR)
- Adnan Menderes University (TR)
- Muğla University (TR)
- Harran University (TR)
- Gazi University (TR)
Publication Details
- Journal
- Scientific Reports
- Published
- 2025-04-05
- DOI
- https://doi.org/10.1038/s41598-025-96157-6
- Citations
- 5
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 5.23