Association between albuminuria and left ventricular diastolic dysfunction.

Introduction: Albuminuria is a common finding in patient with heart failure with an established prognostic value and a potential diagnostic benefit. However, its role in LVDD diagnosis is still under investigation.Aim of the study: To study the association between albuminuria (microalbuminuria and macroalbuminuria) and LVDD.Subjects and Methods: A cross-sectional study involved 200 Patients presenting with exertional dyspnea (NYHA II/III) and an ejection fraction of 50% or more. Urine samples were collected and analysed for UACR. Average E/e’, Septal e’ velocity and Lateral e’ velocity. TR peak velocity and LA volume index were used to identify patients with LVDD. Results: We found albuminuria levels show a statistically significant positive correlation with the four recommended echo variables of LVDD: annular e’ velocity septal (r = 0.31 with a p-value of <0.01), lateral (r = 0.23 with a p-value of <0.01), average E/e’ ratio (r = 0.38 with a p-value of <0.01), LA maximum volume index(r = 0.29 with a p-value of <0.01), and peak TR velocity(r = 0.25 with a p-value of <0.01). a statistically significant higher level of Albuminuria (UACR) was found among cases with diastolic dysfunction with p-value <0.01.Conclusions: There is an association between albuminuria and LVDD. As a simple and cheap investigation, it has a potential to be used as a test in patients with suspected diastolic dysfunction.