Fibre density and cross-section associate with hallmark pathology in early Alzheimer’s disease
Our results suggest that WM degeneration already occurs in the aMCI stage of AD and alterations in apparent fibre density and fibre cross-section of the temporal cingulum bundle are associated with AD hallmark pathology.
Authors
- Stefan Sunaert (ORCID: https://orcid.org/0000-0002-1177-4680)
- Daan Christiaens (ORCID: https://orcid.org/0000-0001-8323-5451)
- Ahmed Radwan (ORCID: https://orcid.org/0000-0002-4819-548X)
- Jeroen Blommaert (ORCID: https://orcid.org/0000-0002-4746-9688)
- Greet Vanderlinden (ORCID: https://orcid.org/0000-0002-5673-4121)
- Michel Koole (ORCID: https://orcid.org/0000-0001-5862-640X)
- Mathieu Vandenbulcke (ORCID: https://orcid.org/0000-0001-9765-1499)
- Koen Van Laere (ORCID: https://orcid.org/0000-0001-5200-7245)
Institutions
- Universitair Ziekenhuis Leuven (BE)
- VIB-KU Leuven Center for Brain & Disease Research (BE)
- KU Leuven (BE)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2025-04-05
- DOI
- https://doi.org/10.1186/s13195-025-01710-0
- Citations
- 6
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 8.16
Funders
- Fonds Wetenschappelijk Onderzoek
- KU Leuven