Evaluation of arthrocentesis with and without platelet rich plasma injection in patients with disc displacement with reduction. A randomized controlled clinical trial

Objectives: The current study aimed to assess the effect of arthrocentesis followed byinjection of platelet rich plasma (PRP) versus arthrocentesis in the management of anteriordisc displacement with reduction (DDWR) disorder. Materials and methods: Seventy-fourpatients ( mean age 29.3 years) with anterior DDWR were randomized and divided accordingto a predetermined eligiblity criteria into two equal groups: arthrocentesis (control) andarthrocentesis with PRP injection ( study).For both groups, Pain intensity was assessed usingvisual analogue scale and maximum mouth opening (MMO) preoperatively, immediate, 1week, 1 month, 3 and 6 months postoperatively. Moreover, the disc displacement angle wasrecorded preoperative and after 6 months. Results: Pain was significantly reduced in thestudy group compared to the control group only at 1 week, 1 month, 3 and 6 months (p <0.05). However, there was non significant difference among groups regarding MMO at all timeintervals or disc position angle after 6 months (p>0.05). Conclusions: PRP resulted in painreduction for most of the period of follow up, with no apparent positive effect on MMO or discposition. Clinical Relevance: The study evaluates whether the anti-inflammatory and growthstimulation effect of PRP is reflected on reduction of pain intensity and disc position in themanagement of patients suffering from DDWR. Clinical trial registration NCT05983653