Photobiomodulation modulates mitochondrial energy metabolism and ameliorates neurological damage in an APP/PS1 mouse model of Alzheimer’s disease
PBM regulates neuroinflammatory response and inhibits neuronal apoptosis, thereby repairing Aβ-induced neuronal damage and cognitive dysfunction. Mitochondrial energy metabolism plays an important role in PBM in improving nerve injury in AD mice. This study provides theoretical support for the subsequent application of PBM in the treatment of AD.
Authors
- Hongli Chen (ORCID: https://orcid.org/0000-0001-5580-707X)
- Xunbin Wei (ORCID: https://orcid.org/0009-0005-0784-7794)
- Tao Tan (ORCID: https://orcid.org/0000-0002-4571-3296)
- Na Liu (ORCID: https://orcid.org/0000-0002-0729-6073)
- Guoshuai Luo (ORCID: https://orcid.org/0000-0002-0286-4369)
- Huijuan Yin (ORCID: https://orcid.org/0000-0002-4821-7562)
- Xiaoxi Dong (ORCID: https://orcid.org/0000-0003-3852-331X)
- Na Li (ORCID: https://orcid.org/0000-0002-0392-6672)
- Chunyan Ma
- Hongyu Zhu
- Xinyu Shi (ORCID: https://orcid.org/0009-0007-9457-5145)
- Yutong Ye (ORCID: https://orcid.org/0000-0002-6874-5741)
Institutions
- Tiangong University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- Peking University Cancer Hospital (CN)
- Tianjin Anding Hospital (CN)
- Cangzhou Normal University (CN)
- Ministry of Education (ET)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2025-04-05
- DOI
- https://doi.org/10.1186/s13195-025-01714-w
- Citations
- 20
- Primary Topic
- Laser Applications in Dentistry and Medicine
- Type
- article
- Field-Weighted Citation Impact
- 27.20
Funders
- National Natural Science Foundation of China