Role of Senescence-Associated Biomarkers and Immune Dynamics in Predicting Response to Neoadjuvant Chemoradiotherapy in Rectal Cancer
IL-1α, CCL2, and CD8+ T cells, were identified as candidate markers that might monitor nCRT effectiveness in rectal cancer patients. These findings reinforce insights into the tumor microenvironment modulated by SASP components and immune cells and imply the need for larger studies to validate such associations.
Authors
- Chenchen Wu (ORCID: https://orcid.org/0009-0005-6445-1905)
- Xue Jiao (ORCID: https://orcid.org/0000-0002-2936-2166)
- Yandong Liu (ORCID: https://orcid.org/0000-0002-4752-9484)
- Xiao Lu (ORCID: https://orcid.org/0000-0002-4637-3916)
Institutions
- Soochow University (CN)
- First Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- International Journal of General Medicine
- Published
- 2025-04-01
- DOI
- https://doi.org/10.2147/ijgm.s508428
- Citations
- 2
- Primary Topic
- Colorectal Cancer Surgical Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- Thomas Jefferson University
- National Natural Science Foundation of China