The effects of Modic-III change on the osseointegration in cervical disc prosthesis: an experimental study in caprine models
The Modic-III changes significantly impaired the osseointegration of artificial cervical disc in caprine models by reducing the number of osteoblasts, BV/TV, Tb.N, Tb.Th, bone ingrowth percentage and down-regulating the expression levels of ALP, Osteocalcin, and Runx-2, possibly leading to more occurrence of prosthesis complications.
Authors
- Hu Xu (ORCID: https://orcid.org/0000-0002-0429-8217)
- Lin Chen (ORCID: https://orcid.org/0000-0002-9795-3275)
- Hao Liu (ORCID: https://orcid.org/0000-0002-6938-8774)
- Yi Yang (ORCID: https://orcid.org/0009-0007-6082-3307)
- Zhigang Xiu
Institutions
- Zunyi Medical University (CN)
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Affiliated Hospital of Zunyi Medical College (CN)
Publication Details
- Journal
- BMC Musculoskeletal Disorders
- Published
- 2025-04-05
- DOI
- https://doi.org/10.1186/s12891-025-08567-2
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Sichuan University
- Sichuan Province Science and Technology Support Program
- West China Hospital, Sichuan University