Human neural stem cell-derived exosomes activate PINK1/Parkin pathway to protect against oxidative stress-induced neuronal injury in ischemic stroke
These findings suggest that hNSC-Exos alleviate OS-induced neuronal damage by regulating the PINK1/Parkin pathway. These reveals a novel role of stem cell-derived mitochondrial therapy in promoting neuroprotection and suggest their potential as a therapeutic approach for OS-associated CNS diseases, including IS.
Authors
- Chengcheng Tan (ORCID: https://orcid.org/0000-0002-4944-2219)
- Yubing Huang (ORCID: https://orcid.org/0009-0002-4131-6952)
- S Zhang
- Shuaiyu Zhu
- Mengke Zhao (ORCID: https://orcid.org/0000-0003-0142-3470)
- Jiayi Wang (ORCID: https://orcid.org/0000-0003-1688-2864)
- Liang Wang (ORCID: https://orcid.org/0000-0003-2244-7535)
- Chao Han (ORCID: https://orcid.org/0000-0002-0363-8283)
- Zhong-Yue Sun
- Jing Liu (ORCID: https://orcid.org/0009-0004-6945-5502)
Institutions
- Dalian Medical University (CN)
- Dalian University of Technology (CN)
- First Affiliated Hospital of Dalian Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-04-05
- DOI
- https://doi.org/10.1186/s12967-025-06283-y
- Citations
- 20
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 16.12
Funders
- National Natural Science Foundation of China