AN INSIGHT INTO ANTITHROMBOTIC DRUG DELIVERY EFFICACY BY COMPUTATIONAL FLUID DYNAMICS

This research rigorously evaluates the effectiveness of antithrombotic medications administered through endovascular techniques, an essential area of study with significant implications for the treatment of blood clots that obstruct circulation. By analyzing the proportion of the drug that reaches the thrombus, we can gain valuable insights into its efficacy. Utilizing the Galerkin finite element method, we simulated an arteriole containing a thrombus, employing the non-Newtonian Carreau–Yasuda blood model. Through the examination of particle trajectories, we uncovered noteworthy findings. In particular, the percentage of drug transmission through the thrombus (%DPtT) consistently hovers around 33.622%, a figure that remains stable regardless of the total number of drug particles. This underscores a critical issue: The flow patterns surrounding the thrombus significantly limit the efficacy of injected drugs. Therefore, it is imperative to consider strategies for distributing these drugs across the cross-section of the arteriole. Addressing this challenge is vital, as it may greatly enhance the effectiveness of antithrombotic therapies, ensuring a larger proportion of the administered drugs reaches their intended target.