Gene expression analysis in circulating tumour cells to determine resistance to CDK4/6 inhibitors plus endocrine therapy in HR + /HER2- metastatic breast cancer patients
CTC gene expression provides information about treatment outcomes in HR + /HER2- metastatic BC patients receiving CDK4/6i plus ET and could guide personalized strategies and improve prognosis.
Authors
- Sabine Kasimir‐Bauer (ORCID: https://orcid.org/0000-0002-8081-1799)
- Carmen Abuín (ORCID: https://orcid.org/0000-0002-6902-4161)
- Rafael López‐López (ORCID: https://orcid.org/0000-0003-1315-655X)
- Manuel J. Aybar (ORCID: https://orcid.org/0000-0002-7187-6435)
- Corinna Keup (ORCID: https://orcid.org/0000-0003-3525-7511)
- Miriam González-Conde
- Clotilde Costa (ORCID: https://orcid.org/0000-0001-7327-2259)
- Celso Yáñez
- Tomás García‐Caballero (ORCID: https://orcid.org/0000-0002-7938-1437)
- Alexandra Cortegoso (ORCID: https://orcid.org/0000-0003-4098-9266)
- Laura Muinelo‐Romay (ORCID: https://orcid.org/0000-0002-7456-7531)
- Teresa Curiel (ORCID: https://orcid.org/0000-0003-2791-9554)
- Juan Cueva (ORCID: https://orcid.org/0000-0003-1389-4595)
- Carmela Rodríguez
- Ramón Manuel Lago‐Lestón (ORCID: https://orcid.org/0000-0002-1166-7754)
- Marta Carmona
- Patricia Palacios
- Lucía Pedrouzo
Institutions
- Universidade de Santiago de Compostela (ES)
- Essen University Hospital (DE)
- Instituto de Investigación Sanitaria de Santiago (ES)
- Servicio Gallego de Salud (ES)
- Centro de Investigación Biomédica en Red de Cáncer (ES)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-04-04
- DOI
- https://doi.org/10.1186/s12967-025-06374-w
- Citations
- 2
- Primary Topic
- Advanced Breast Cancer Therapies
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- European Commission
- Fundación Científica Asociación Española Contra el Cáncer
- Axencia Galega de Innovación
- Xunta de Galicia
- Instituto de Salud Carlos III
- European Regional Development Fund
- Servicio Gallego de Salud