IRAP Drives Ribosomal Degradation to Refuel Energy for Platelet Activation during Septic Thrombosis (Adv. Sci. 13/2025)
Insulin‐Regulated Aminopeptidase In septic platelets, insulin‐regulated aminopeptidase (IRAP) adsorbs ribosomal proteins and cooperates with autophagosomal proteins to promote lysosomal degradation of r‐proteins, thereby providing amino acids required for durative glycolysis, which ensures mitochondrial function and finally provides abundant ATP for prolonged platelet activation. In addition, IRAP is also involved in SNARE complex assembly to facilitate granules release. More details can be found in article number 2411914 by Jinghong Zhao, Junping Wang, Shilei Chen, and co‐workers. [Image: see text]
Authors
- Shilei Chen (ORCID: https://orcid.org/0000-0003-3362-2909)
- Song Wang (ORCID: https://orcid.org/0000-0003-3116-5038)
- Qigang Lan (ORCID: https://orcid.org/0000-0001-9697-9206)
- Kangfu Sun (ORCID: https://orcid.org/0000-0001-7331-4025)
- Yang Xu (ORCID: https://orcid.org/0000-0001-6861-7814)
- Xianpeng Ye
- Zhaoyang Wen
- Mo Chen (ORCID: https://orcid.org/0000-0001-7226-6789)
- Jun Chen (ORCID: https://orcid.org/0000-0002-6513-9084)
- Xi Zhang (ORCID: https://orcid.org/0000-0001-7033-8478)
- Jinghong Zhao
- Mingqiang Shen
- Liang Chen
- Junping Wang (ORCID: https://orcid.org/0000-0003-1190-1448)
- Baichuan Xu (ORCID: https://orcid.org/0000-0002-6107-9088)
Publication Details
- Journal
- Advanced Science
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/advs.202570086
- Primary Topic
- Hepatitis C virus research
- Type
- article
- Field-Weighted Citation Impact
- 0.00