CXCL12/CXCR4 axis mediates CD8 + T cell overactivation in the progression of viral myocarditis
These findings provide deeper insights into the immune landscape of pediatric FM, uncovering a novel role of the CXCL12/CXCR4 axis in driving CD8<sup>+</sup>T cell responses in myocarditis. Furthermore, they highlight the CXCL12/CXCR4 axis as a promising therapeutic target for myocarditis treatment.
Authors
- Shan Zhou (ORCID: https://orcid.org/0000-0001-9067-6802)
- Bo Han (ORCID: https://orcid.org/0000-0001-5286-372X)
- Xiuyun Duan
- Yingnan You (ORCID: https://orcid.org/0009-0005-5139-2977)
- Hailin Jia (ORCID: https://orcid.org/0000-0002-4051-1089)
- Li Zhang (ORCID: https://orcid.org/0000-0002-2165-8587)
- Keyu Liu (ORCID: https://orcid.org/0000-0002-8429-8267)
Institutions
- Shandong University (CN)
- Shandong Provincial Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-04-04
- DOI
- https://doi.org/10.1186/s12967-025-06394-6
- Citations
- 6
- Primary Topic
- Viral Infections and Immunology Research
- Type
- article
- Field-Weighted Citation Impact
- 8.33
Funders
- Jinan Science and Technology Bureau
- Natural Science Foundation of Shandong Province
- Taishan Scholar Foundation of Shandong Province