<i>D2HGDH</i> Deficiency Regulates Seizures through GSH/Prdx6/ROS‐Mediated Excitatory Synaptic Activity (Adv. Sci. 13/2025)

D2HGDH Deficiency Regulates Seizures Epilepsy is a disease associated with oxidative stress. On article number 2404488, Xin Tian, Yuanlin Ma, Patrick Kwan, and co‐workers report that the D2HGDH gene can be involved in seizures by regulating neuronal oxidative stress levels. This cover uses an analogy to illustrate the brain's oxidative stress mechanism. The fall of the moat symbolizes the imbalance of GSH/GSSG metabolism. This imbalance weakens the defense, leading to the city being captured, much like how the elevation of ROS impairs neural function. Specifically, the impairment of neural function is comparable to the loss of important command centers (like the brain), and the excessive excitation of neurons is represented by the ‘smoke of fire’ after the city's capture. This indicates that D2HGDH is a causal link between oxidative stress and epilepsy. [Image: see text]