Fucoidan reduces NET accumulation and alleviates chemotherapy-induced peripheral neuropathy via the gut–blood–DRG axis
Altogether, fucoidan promotes the SR-A1-mediated phagocytosis of LPS/HMGB1/NETs and maintains gut microbial homeostasis, which may provide a potential therapeutic strategy for CIPN.
Authors
- Lijuan Zong
- Chen Miao (ORCID: https://orcid.org/0009-0006-3826-1590)
- Wentao Liu (ORCID: https://orcid.org/0000-0001-5534-7173)
- Li Wan (ORCID: https://orcid.org/0000-0002-0531-4573)
- Yihang Cai
- Mengyao Zhang (ORCID: https://orcid.org/0000-0002-8353-7465)
- Rumeng Jia
- Liang Hu (ORCID: https://orcid.org/0000-0002-0013-7440)
- Yajie Zhang (ORCID: https://orcid.org/0000-0003-2510-6015)
- Xia Zhu
- Yongyi Chen (ORCID: https://orcid.org/0000-0002-3226-7311)
- Jianxin Ma
- Lai Jin
- Xuefeng Wu
- Qingyan Tian
Institutions
- Nanjing University of Chinese Medicine (CN)
- Lianyungang Oriental Hospital (CN)
- Jiangsu Cancer Hospital (CN)
- Jiangsu Province Hospital (CN)
- Nanjing Medical University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2025-04-04
- DOI
- https://doi.org/10.1186/s12974-025-03431-5
- Citations
- 10
- Primary Topic
- Polysaccharides and Plant Cell Walls
- Type
- article
- Field-Weighted Citation Impact
- 17.50
Funders
- National Natural Science Foundation of China